Prolonged intake of prebiotics and probiotics may help reduce disorders related to alcohol addiction

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The intestinal microbiota plays a crucial role in the health of individuals, which is why we must try to keep it in a balanced state, called eubiosis.


Recently, the Research Group on Integrated Pharmacology and Systems Neuroscience of the Hospital del Mar Institute for Medical Research (IMIM-Hospital del Mar) and the CIBER on Physiopathology of Obesity and Nutrition (CIBEROBN), in collaboration with Microomics Systems as microbiome experts, has published the first study that analyzes how maintaining a healthy gut microbiome can reduce the harmful effects of addictive alcohol consumption.

The study, which has funded the National Drug Plan of the Ministry of Health and has been published in the journal Frontiers in Nutrition, is the first to establish a direct relationship between bacteria living in the intestine, brain and addictive behavior. The researchers analyzed in mice the relationship between alcohol intake and the gut microbiota, which is already considered as an organ of the body. In this case, one group of animals received a week-long supplementation with a mixture of prebiotics and probiotics, a symbiotic, to stimulate the growth of beneficial bacteria in their gut, while another group, the control group, received a conventional feeding. All animals were then subjected to intermittent exposure to alcohol for 20 days, alternating alcohol consumption with that of symbiotic or water, in the case of the control group. At the end of this period, the supply of alcohol was interrupted for seven days, to be offered again and to analyze if there was a relapse in consumption.

The results of the tests show that those animals that had received prebiotic and probiotic feeding showed a lower escalation in alcohol consumption. In addition, the relapse after the interruption of alcohol intake was lower. This shows, according to Dr. Patricia Robledo, researcher at IMIM-Hospital del Mar and lead author of the paper, that “the implementation of a diet rich in symbiotics can prevent addictive behavior related to chronic alcohol consumption, since its intake produces changes in the gut microbiota and in certain neurotransmitters of the brain”. That is, the study “explores whether modulation of the gut-brain axis (the two-way communication system between the gut microbiota and the brain) could prevent alcohol-related disorders,” she says.

The animals were also subjected to behavioral studies to measure how dietary intervention with a symbiotic modulated behavioral alterations associated with alcohol addiction withdrawal disorder. The study shows that the females suffered depression, anxiety and memory alterations, but to a lesser extent in those that had seen their gut microbiota strengthened. Finally, concentrations of tryptophan metabolites and neurotransmitters such as noradrenaline, dopamine and serotonin in the prefrontal cortex and hippocampus (areas related to addictive behaviors, depression, anxiety and memory) were examined, their levels are affected differently depending on the sex and state of the gut microbiota.

Therefore, it was shown that “modulating the intestinal microbiota, can affect addictive behavior”, says Dr. Neus Pizarro, signatory of the paper and also researcher of the IMIM-Hospital del Mar, which states that “what we have achieved with the symbiotic is to reduce the adverse effects of alcohol on the composition of the intestinal microbiota and thus avoid its repercussion to the brain”.

In the words of Dr. Rafael de la Torre, coordinator of the Research Group on Integrated Pharmacology and Systems Neurosciences of the IMIM-Hospital del Mar and researcher of the CIBEROBN, maintain a diet rich in prebiotics and probiotics, “is not a magic pill against the possibility of suffering addictive behavior”. In fact, alcohol consumption causes an imbalance in the microorganisms that inhabit the intestine. Therefore, “if we modulate the intestinal microbiota, the changes can be reflected at the cerebral level in the medium and long term. But in no case can the symbiotic be considered a kind of morning-after pill for addictive behaviors”, he adds.

This approach brings us closer to a better understanding of the impact of the health status of the gut microbiota on the modulation of behavioural alterations associated with alcohol addiction disorders, adding the layer of value of the effect of dietary supplementation of prebiotics and probiotics.



Reference article:

Nieves Pizarro, Elk Kossatz, Pedro González, Alba Gamero, Emma Veza, Cristina Fernández, Toni Gabaldón, Rafael de la Torre and Patricia Robledo. Sex-specific effects of synbiotic exposure in mice on addictive-like behavioural alterations induced by chronic alcohol intake are associated with changes in specific gut bacterial taxa and brain tryptophan metabolism. Front. Nutr. 2021

We are 4 years old!

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4th Anniversary of Microomics


There is a highlighted date on the Microomics calendar: October 2017. That month, Microomics was incorporated as a spin-off of the CRG and ICREA that aimed to offer innovative and advanced solutions for the analysis of microbial communities through next generation sequencing technologies.

The excitement has remained throughout these 4 years and, after the pandemic, our mission to bring knowledge to the service of society has been further reinforced.

These 4 years of trajectory would not have been possible without all the groups and companies that have trusted us and from here we show them our sincere gratitude.


Each new project translates into new learning for us too, which allows us to continue working, in line with our values, on our goal to become one of the leading providers of economic analysis and microbial communities.

This is the beginning of a long journey that we hope to continue to enjoy alongside our customers and collaborators, remaining on the side of the scientific community and companies in the sector for many more years.

Strategic collaboration between Microomics and the company Paralab Bio

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Microomics continues to progress towards their vision of becoming a leading national and European provider of metagenomic analysis. 


From now on, Microomics Systems S.L. will be available among the services offered by the company Paralab Bio thanks to the commercial agreement between the two entities. In so doing, Paralab Bio will offer for the first time the service of this type of analysis to their customers. 


Paralab Bio ( is a division of Paralab, created in 2017 with the aim of segmenting its areas of activity. This division distributes scientific equipment for all areas of biosciences (especially with the object of study focused on proteins, genetic material, or cells), both at academic and laboratory or industrial level. Paralab was founded in 1992 to act as a distributor of scientific equipment for industrial and laboratory applications. It has thus become a reference company in the sector. 



With this collaboration, Microomics aims to reach more companies and research groups interested in the study of the microbiome. Our 360° comprehensive service includes advice at all stages of a project, from evaluating which metagenomic tool is the most suitable for the type of sample, through the stages of molecular biology (nucleic acid extraction and library preparation) and bioinformatics and statistical analysis, which is all summarized in a final delivery report. 


This agreement represents the continuous growth that the company is experiencing, which allows us to gradually approach our business vision and excellence in our services. 

Microomics attends BioSpain 2021

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X Edition of BioSpain International Trade Show & Partnering

Today begins the tenth edition of BioSpain International Trade Show & Partnering, which will last until October 1. This year the event will have a dual format, being able to attend both in person in Pamplona-Iruña, Navarre, and online.

BioSpain welcomes leading national and international biotechnology professionals and companies to share knowledge and encourage potential synergies between them.

For the first time, Microomics will attend this event. Pedro Iñaki González, its Co-Founder and CEO will participate in the Microbioma roundtable on Wednesday, September 29 at 17:15h (CEST). In this, each of the experts of the panel will contribute their particular vision and will address the current state of the microbiome and its future perspectives, from different approaches: the most purely academic, the biotechnology and, finally, in the context of the emergence of new business models and financing.

BioSpain promotes interaction among its attendees through its Partnering platform, available throughout the event. If you have registered to BioSpain2021 we encourage you to request a one-to-one meeting, with Pedro, by clicking here or on the button:

Commercial agreement between Microomics and the company Condalab

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Microomics increases the visibility of its services at national level

In September Microomics Systems S.L. reaches a new milestone, as our Metagenomics services will be part of the catalog offered by the company Condalab. This agreement will offer Condalab customers our expertise in research and analysis of microbial communities (microbiomes).

Condalab was born in 1960 as the first Spanish manufacturer of dehydrated culture media for microbiology and molecular biology, being internationally recognized for making key components such as agar, peptone or agarose, among others. In addition, they are exclusive distributors in Spain of companies in the field of molecular and cellular biology of international prestige.

Logo Condalab

With this collaboration, Microomics hopes to reach more companies and research groups that are interested in studying the microbiome. With our comprehensive 360º service, we advise people interested in all stages of a project, from evaluating which metagenomic tool is the most suitable for your type of sample, through the stages of molecular biology (extraction of nucleic acids and preparation of libraries) and bioinformatics and statistical analysis.

The joint mission to contribute to knowledge and progress in the field of life sciences are key points in the philosophy of both parties, which has motivated this collaboration.

As a result of this agreement, Pedro González, CEO of Microomics, will participate in the webinar on September 29, at 10h, promoted by Condalab, where he will talk about metagenomics, its application in clinical and preclinical studies and the future perspective of this technology for microbiome analysis. To register simply click here or on the button and fill in the registration form. We encourage you to sign up and get to know us!

Microomics continues to grow! Two new teammates join the team.

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Microomics welcomes Paula Carreras and Sergio Manresa, who will occupy the position of Manager of the Marketing and Sales Department and NGS Analyst of Microomics Systems S.L., respectively.

Paula is a biotechnologist and specialized in pharmaceutical and biotechnological marketing. She has a multidisciplinary profile obtained during her time in research and in the pharmaceutical industry, specifically in the departments of Patient Advocacy and Marketing. Paula has been part of national and international projects, leading in the health innovation sector.

Sergio, in turn, is a biotechnologist and specialist in NGS sequencing, combining his studies in biomedicine where he developed his knowledge in the human microbiome along with his interdisciplinary dedication between the areas of laboratory and bioinformatics that he obtained in both the public and private sectors.

Both additions to Microomics represent the growth of the company. On the one hand, they represent a step forward in our digital channels and in how to optimize customer/collaborator support to achieve an exclusive and personalized treatment. On the other hand, in the bioinformatics and laboratory area, it represents a key reinforcement in the laboratory area of the company, identifying the needs of our collaborators and customers and bringing them the most relevant technological developments.

Through their new positions we want to promote the company’s R+D+i areas and improve our services, always striving to be at the forefront of new NGS sequencing technologies at the service of our society.

Since the company was born in September 2017, the growth of Microomics has been sustained and we hope that these reinforcements will help us not lose momentum in achieving our goal: to be a reference in the study of the microbiome at a national level.

Welcome to the Microomics team, Paula and Sergio!

The team gets bigger

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A new member in the Bioinformatics Department and creation of the Marketing and Sales Derpartment 

Since January 2021, Microomics has two new members on board: José Castellón, as Data Analyst and Specialist in Statistics; and Rubén Melgarejo, as Manager of the Marketing and Sales.

The company is continually growing since we started on September 2017 and we hope our new colleagues will help as to achieve our objective: to be the Spanish reference for Metagenomics.

Kind Regards,

The Team of Microomics Systems

El equipo de Microomics crece

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Nueva incorporación en el Departamento de Bioinformática y creación del Departamento de Marketing y Ventas

Este Enero 2021, se incorporaron al equipo de Microomics dos nuevos miembros: José Castellón, como Analista de datos y Especialista en Estadística; y Rubén Melgarejo, como Manager del Departamento de Marketing y Ventas.

Desde que nació la empresa en Septiembre 2017, el crecimiento de Microomics ha sido sostenido y esperamos que estos refuerzos nos ayuden a no perder impulso en lograr nuestro objetivo: ser una referencia en análisis metagenómicos a nivel nacional.


El Equipo de Microomics Systems S.L.

New Data Analyst in Microomics

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We welcome Dr. Belén Carbonetto to our team

She will be our Data Analyst and Metagenomics Specialist.

Belén has wide experience in NGS data analysis, mainly for the study of microbiomes by barcoding sequencing and metagenómics. She has a broad background as a researcher  working with interdisciplinary teams in several international institutions.

She will lead Microomics one step forward in Bioinformatics by developing customized solutions and taking advantage of her knowledge and skills as a natural transition from the academy to the applied sciences.

Her contribution will help the evolution and creation of services and products by bringing innovation to our I+D+i projects.
Welcome Belén!

New Lab Manager in Microomics

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We welcome to our team to Nuria Escudero, who will fill the position of Lab Manager of Microomics Systems S.L.

Nuria Escudero is a PhD specialized in plant pathology and biological control at the molecular level. During her research career she has applied different -omics techniques to the study plant parasitic nematodes, antagonist microorganisms, and plant interactions. Nuria has collaborated with both national and international research institutions as well as agricultural companies.

Her incorporation to Microomics means for her a natural professional transition and personal growth, both from the applied research, and from a technical perspective. Therefore, in her position as Lab Manager she will exploit communicative aspects and her skills to adapt and bring the most relevant technological developments to academics and companies in the sector, incorporating emerging technologies as she has been doing throughout her professional career.

Given her research profile, her incorporation into the Microomics team supposes a boost in the R+D+i area of the company. With a broad knowledge in molecular techniques, her incorporation is a key decision for the laboratory area of ​​the company, also contributing significantly to the improvement of our services, their evolution and technological updating, with the purpose of being always at the forefront of new technologies that put NGS sequencing at the service of our society.

With the incorporation of Nuria Escudero, Microomics also incorporates strategic expertise for the agricultural sector, thus covering one of the main areas of interest for the application of NGS. The versatility and initiative of Nuria represent a key element for adapting our technologies, identifying the needs of our partners and clients, and therefore providing innovative solutions at the forefront of research.

Welcome to the Microomics team Nuria!